Galore International Journal of Health Sciences and Research

Original Research Article

Year: 2018 | Month: January | Volume: 3 | Issue: 1 | Pages: 1-4

Preparation and In-Vitro Evaluation of Sodium Alginate Based Gastroretentive Floating Tablet of Domperidone

Tushar Saha1, Zia Uddin Masum1 and Sania Ashrafi2

1Department of Pharmaceutical Technology, 2Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Corresponding Author: Tushar Saha


The current study demonstrates the preparation and in vitro evaluation of gastroretentive floating tablet of Domperidone where sodium alginate was used as release controlling polymer. For gas generating agent, sodium bicarbonate was used. Tablet was prepared by direct compression technique. Physical parameters, in vitro buoyancy study, total floating time and zero order drug release study were performed. 0.1N HCl (pH 1.2) was used as dissolution medium which was used in USP II apparatus for 12 hours in orderto find out the drug release pattern. Evaluated physical parameters were within acceptable range. Compatibility between drug and polymer was found in Fourier Transform Infrared Spectroscopy (FTIR) study.

Key words: Gastro retentive floating tablets, sodium alginate, compatibiltyy

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