Original Research Article
Year: 2018 | Month: July | Volume: 3 | Issue: 3 | Pages: 8-13
Correlation of Vitamin-D Levels With Blood Sugar Levels in Diabetes Mellitus
Dr.K.Sudhakar Naidu1, Dr.K.Madhurima Naidu2, Dr.Pruthvi3, Dr.B.Vodelu4
1Assistant Professor, 4Professor, Department of Biochemistry,
Maheshwara Medical College & Hospital, Sangareddy, Telangana
2Senior Resident, Department of Orthopedics, MNR Medical College & Hospital, Sangareddy, Telangana
3Senior Resident, Department of Orthopedics, Mallareddy Institute of Medical Sciences, Hyderabad, Telangana
Introduction: Diabetes is the major disease prevalent throughout the world irrespective of the region, religion, food habits, age, gender, socioeconomic status, nutritional status of the present day population. Because of the complications and the effects of increased blood sugar levels in an individual, the world is more concerned about Diabetes. Furthermore, vitamin D is known to have immuno-modulatory and anti-inflammatory effects, which could improve peripheral insulin resistance by altering low-grade chronic inflammation that has been implicated in insulin resistance in type 2 diabetes mellitus.
Materials & Methods: The present analysis was based on a cross-sectional study design carried out at the outpatient department of Maheshwara Medical College & Hospital. Subjects were selected through the simple random sampling method, and data collected using a structured questionnaire. A total of about 354 people have given their consent for participating in the present study. Out of these, 200 subjects (100 diabetics and 100 non-diabetics) were randomly included in the present analysis after considering the inclusion and exclusion criteria. Venous blood samples were drawn after overnight fasting for the measurement of serum glucose, creatinine and total cholesterol. Serum was also stored at -30°C for measurement of 25(OH)D. Serum 25(OH)D was determined by radioimmunoassay (Diasorin 25-hydroxyvitamin D 125I RIA Kit, Stillwater, Minnesota, USA) in the Clinical Biochemistry Laboratory. The results were averaged as (mean ± standard deviation) for each parameter subgroups separately for Diabetics& Non-diabetics. Statistical analysis was done using IBM SPSS Statistics 20 package.
Results: The mean values of Vitamin D levels in diabetics & non-diabetics are 19.97 and 31.43 respectively. Mean Blood Sugar is found to be 171.86 in diabetics and 134.56 in non-diabetics. On statistical analysis of the findings, it was found that the levels of vitamin D are significantly low in diabetics when compared with non-diabetics.
Discussion: In the present study, the correlation between the levels of vitamin D and blood sugar is highly significant. This signifies the probability of correlation of vitamin D levels with the blood sugar levels of the individuals. Decreased vitamin D was significantly correlated to insulin resistance and decreased β-cell function of Pancreas. It would be useful, though to undertake further studies to discover more about the mechanism and the effect of vitamin D on both alpha and islet beta-cell function and also on the mechanisms determining insulin resistance.
Key words: Vitamin D, Diabetes, Insulin Resistance.