Original Research Article
Year: 2018 | Month: July | Volume: 3 | Issue: 3 | Pages: 28-33
Biochemical Evaluation of Trigonella Foenum-Graecum Seed Extract in Metabolic Syndrome
Mrinalini S. Patwardhan1, Vinayak W. Patil2, Sanjeev Y. Patwardhan3, Shubhangi M. Dalvi4, Neelam Yeram1
1Research Scholar, 2Professor and Head, 4Associate Professor,
Department of Biochemistry, Grant Government Medical College and Sir J. J. Group of Hospitals, Mumbai 400008.
3Pathologist, Satyajit Clinic, Furniture Bazar, Ulhasnagar- 421003.
Background: Metabolic syndrome is a crucial factor in causation of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). Fenugreek seeds have beneficial effects on improvement of metabolic syndrome.
Objective: Evaluation preventive and curative efficacy of aqueous extract of fenugreek seeds in metabolic syndrome by observation of biochemical parameters and its correlation.
Methods: Case control study consisting of controls (n=34) and subjects (n=34) with metabolic syndrome. Case group was administered aqueous extract of fenugreek seeds equivalent to 13.2gm powder/day for 3 months. Both groups were evaluated at base line and after three months while status quo was maintained. Subjects were advised not to alter their lifestyle.
Results: After three months of adjunct therapy, there was significantly improvement in glycaemic status, insulin resistance, HOMA, and antioxidant superoxide dismutase (SOD) in metabolic syndrome when compared with control group.
Conclusion: Aqueous extract of fenugreek seeds is effective and safe to control glycaemic, insulin resistance, dyslipidaemias and antioxidant status in metabolic syndrome.
Key words: Fenugreek, metabolic syndrome, HbA1c, HOMA, SOD.