Year: 2026 | Month: July-September | Volume: 11 | Issue: 3 | Pages: 46-55
DOI: https://doi.org/10.52403/gijhsr.20260306
Targeted Nutritional Intervention in PMOS-Associated Metabolic Dysfunction: A Root Cause Analysis & Functional Nutrition-Driven Case Study
Atharva Lokhande1, Aakansha Tamhane2, Saloni Kulkarni3, Mugdha Pradhan4
1B.Pharm., Researcher, ThriveTribe Wellness Solutions Pvt. Ltd. Pune.
2MSc., Senior Functional Nutritionist, ThriveTribe Wellness Solutions Pvt. Ltd. Pune.
3MSc., Head of Client Services, Thrive Tribe Wellness Solutions Pvt. Ltd. Pune.
4MSc., Expert Functional Nutritionist, CEO, ThriveTribe Wellness Solutions Pvt. Ltd. Pune.
Corresponding Author: Atharva Lokhande
ABSTRACT
Polycystic Ovary Syndrome (PCOS), also now known as Polyendocrine Metabolic Ovarian Syndrome (PMOS) is a complex multi-systemic endocrine-metabolic condition closely linked to insulin resistance (IR), chronic inflammation, ovulatory dysfunction, and hyperandrogenism. In this article, we highlight the clinical outcomes associated with a functional nutrition intervention aimed at correcting the underlying factors contributing to metabolic dysfunction in a 28-year-old female with PCOS (PMOS). Identified patient issues included metabolic dysfunction and obesity, chronic abnormal uterine bleeding (AUB)/secondary amenorrhea, IR, fatigue, anxiety, nutrient deficiencies, as well as biochemical imbalances including a HOMA-IR of 4.1, hyperinsulinemia, dyslipidaemia, elevated hs-CRP/ESR, vitamin D and B12 deficiency, severe iron deficiency, and infrequent periods with AUB lasting 45-60 days.
Nutritional counselling cantered on implementing a low-glycaemic, high-fiber, protein-balanced diet. In addition, the patient was advised to begin supplementation with myo- inositol, N- acetyl cysteine (NAC), magnesium glycinate, omega-3s, iron, and biogymnema. Lifestyle interventions also included resistance exercise, circadian health optimization, stress management, and avoidance of endocrine-disrupting chemicals.
Improvements were made in several metabolic, hormonal, and inflammatory parameters after 24 weeks. These included improvements in HOMA-IR (0.66), insulin levels, waist circumference, cycle regularity (29-31 days), and decreased duration of AUB. Furthermore, hs-CRP and ESR were decreased, as well as improvements in her LDL particle size, total cholesterol, and triglycerides. The patient also noted increases in energy, mood, sleep, and focus. Overall, this case demonstrates the benefits of a root-cause, functional nutrition intervention in improving PMOS-associated metabolic dysfunction.
Keywords: Polycystic Ovary Syndrome (PCOS), Polyendocrine Metabolic Ovarian Syndrome (PMOS), targeted nutritional intervention, functional nutrition