Original Research Article
Year: 2018 | Month: January | Volume: 3 | Issue: 1 | Pages: 18-23
Evaluation of Antifungal Activity of Ethanolic Crude extract of M. Hirtus Plant against Dermatophytes
Ado Aminu B/kudu1, John Odda2, Adamu Almustapha Aliero3, Joseph Oloro4
1Department of Pharmacology and Toxicology, Kampala International University
2Senior Lecturer, Department of Pharmacology and Toxicology, Kampala International University
3Department of Microbiology and Immunology, Kampala International University
4Senior Lecturer, Department of Pharmacology and Toxicology, Kampala International University
Corresponding author: Ado Aminu B/kudu
ABSTRACT
Introduction: Plants are considered among the important sources of bioactive compound, especially in traditional medicine that has been used for centuries. Although ethno botanical surveys have reported wide use of Mitracarpus hirtus in traditional medicine, but there is hardly scientific literature on fungal efficacy regarding to M. hirtus.
Objective: the purpose of this study was to determine antifungal activity of M. hirtus against dermatophytoses.
Methodology: The herb was collected from the bush and dried under normal room temperature, and maceration process was use for the extraction. The Agar well diffusion method was used for Antifungal activity, as well as tube dilution method for the MIC.
Result: The M. hirtus whole plant showed antifungal activity with mean values zone of inhibition at different concentration, and wide zone of inhibition was obtain at 1500mg/ml (22mm) for E. floccosum (20mm) for Trichophyton sp, and (19mm) Microsporum sp. MIC of Microsporum was obtain at 70µg/ml, 60µg/ml of Trichophyton sp, and E. floccosum 50µg/ml. The conclusion from this study is that M. hirtus plant extract has antifungal activity against E. floccosum, Trichophyton sp, and Microsporum sp almost similar with commercial fungicidal drugs (Terbinafine).
Key words: Mitracarpus hirtus, Dermatophytes.