Original Research Article
Year: 2021 | Month: October-December | Volume: 6 | Issue: 4 | Pages: 26-41
DOI: https://doi.org/10.52403/gijhsr.20211006
A Study on Pharmacist Mediated Intervention in Identifying and Reporting of Adverse Drug Reactions at a Tertiary Care Hospital
Mohsina F.P1, Faheem I.P2, Aquil-ur-Rahim Siddiuque3, Abhinandan Patil4, Mohammad A Kamal5,6,7, Mukim M8
1,2Luqman College of Pharmacy, Gulbarga, Karnataka, India
3Shri Bhagwan College of Pharmacy, Aurangabad, Maharashtra, India
4Sanjay Ghodawat University, Kolhapur, Maharashtra, India
5King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia
6West China School of Nursing / Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
7Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia
8Kota College of Pharmacy Kota, Kota Rajasthan, India.
Corresponding Author: Mohsina F.P
ABSTRACT
Background: Adverse drug reactions are major problem in health care system due to its consequences - morbidity, mortality and health care cost. Recent epidemiologic research reveals that the total incidence rate of ADRs was 6.7%, with an overall fatality rate of 0.32%.
Method: A prospective observational study was carried out for 6 months in a tertiary care hospital. Patients admitted to the department of medicine, Pediatrics, orthopedics & surgery were selected randomly and followed from date of admission to date of discharge by enrolling into the study by considering the study criteria.
Results: During the research about 27 ADRs were recognized & reported. Among them 14 (51.86%) patients were male and 13(48.14%) were female patients. The system or organ most commonly involved was Blood disorders were 8 (29.62%). Type A were 16(57.25%) reactions followed by Type B were 8 (29.62%); Type C were 3 (11.11%). Study depicts drug class usually implicated with ADRs was Antibiotics and antineoplastic drugs were 6 (22.22%) followed by Anti-Tubercular were 3 (11.11%); NSAIDS and Antidiabetic drugs were 2 (7.4%); The least implicated (3.7%) drug class are Anti-Pyretic, Diuretics and Antiretroviral. Causality was assessed for all the reported reactions are found to be PROBABLE according to WHO-UMC Scale.
Conclusion: The study report shows that incidence of ADRs is steadily increasing. Under reporting of ADR is a major problem in India. Clinical Pharmacist plays a vital role in surveillance and prevention of ADRs.
Keywords: Adverse Drug Reactions, Pharmacovigilance, Causality.