Original Research Article
Year: 2018 | Month: October-December | Volume: 3 | Issue: 4 | Pages: 23-28
Study On Drug Solubilisation and Synergism Using Prominently Used Non Ionic Surfactants and Sodium Lauryl Sulphate
Md. Bodiuzzaman Rabbi, Iftekhar Ahmed, A.S.M. Mominul Haque, Sultana Ameena, Sakina Sultana
Department of Pharmacy, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
Corresponding Author: Iftekhar Ahmed
ABSTRACT
In the present study amount of Cefixime and amount of Metronidazole solubilised using PEG 6 K, PEG 20 K, PVP K 30, Brij 30 and Sodium lauryl sulphate alone and in combinations was investigated. Study results showed that drug amount solubilised by single surfactant was higher than water for both drugs and values were noticeable for Brij 30 and Sodium lauryl sulphate. Regarding drug amount solubilised using surfactant combination results showed synergistic effects and the effect was prominent when Brij 30 and Sodium lauryl sulphate were present in combination.
Key words: PEG 6 K, PEG 20 K, PVP K 30, Brij 30, Sodium lauryl sulphate, synergism and drug solubilisation