Original Research Article
Year: 2019 | Month: January-March | Volume: 4 | Issue: 1 | Pages: 91-98
Formulation and Preparation of Theophylline “Sonophoric Gel”
Jannatul Fardous1, Faria Farzana Perveen1, Md Sayem Hossain1, Prodip Kumar Baral1,2, Sakina Sultana1
1Dept. of Pharmacy, Jahangirnagar University, Savar, Dhaka, Bangladesh
2Dept. of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
ABSTRACT
Purpose: This study was conducted to investigate gel rheology and extent of drug release across a microfilm (simulating a biological membrane), under the influence of ultra sound energy & dissolution along with determining changes in potency, gel syneresis and gel swelling over 60 days.
Materials and Methods: In the study the sonophor gel was formulated and prepared following the process as described by Lloyd, 2005 where carbopol (934) was used as a gelling material and plain distilled water was used as the solvent. The formula was customized and the drug used in the formula was theophylline (anhyd.) taken in an amount of 1%.
Results: Study results showed pseudoplastic flow of the sonophor gel and exponential term of the plot was found greater than unity. Tests involving determination of extent of drug release across a microfilm (simulating a biological membrane), under the influence of ultra sound energy & dissolution, results showed although the presence of microfilm reduced extent of drug release yet sonication increased drug release by many folds irrespective of the presence and absence of the microfilm barrier. Regarding dissolution, extent of drug release was 17% in 45 minutes. Regarding investigation on changes in gel potency, gel-syneresis and gel-swelling over the specified time period results failed to show noticeable changes in potency and there occurred no gel-syneresis and no gel-swelling.
Conclusion: It is possible to formulate and prepare a stable Theophylline “Sonophoric gel” which might be used as an alternative for asthmatics when results would be simulated further for clinical studies
Key words: Gel, Sonophor, theophylline, rheology and extent of drug release