Original Research Article
Year: 2019 | Month: October-December | Volume: 4 | Issue: 4 | Pages: 55-60
Study of Serum IMA and Electrolytes in Patients of Pre-eclampsia in Central India
Dr. Navanil Roy1, Dr. Laxmikanth Bachu2
1Associate Professor, Department of Biochemistry, Rama Medical College Hospital and Research Centre, Kanpur, India
2Professor, Department of Biochemistry, Shri Shankaracharya Institute of Medical Sciences, Junwani, Bhilai, Chhattisgarh, India
Corresponding Author: Dr. Laxmikanth Bachu
ABSTRACT
Background: Pre-eclampsia (PE) a pregnancy specific disorder is the most common cause of fetal and maternal death, yet no specific prevention and treatment is available. Reliable biochemical markers for prediction and diagnosis of PE can have a better impact on maternal health and therefore several markers have been suggested till now. Recently Ischemia Modified Albumin (IMA) has emerged as a marker in different diseases where ischemia is the origin or consequence behind disease pathology. The normal sodium level is in the range of [137-145 mmol/L] and that of the potassium is [3.5-5.0 mmol/L].
Materials & methods: 30 patients with PE were selected for the study and compared with 30 pregnant healthy controls.
IMA, IMA/albumin ratio & Serum Electrolytes were estimated in these patients.
The results were then statistically analyzed. It was a record based cross-sectional comparative study, carried out in the department of Biochemistry at Shri Shankracharya Institute of Medical Sciences and Hospital, Bhilai (Chhattisgarh) a tertiary care institute.
Results: IMA levels were found significantly raised in PE patients as compared to normal pregnant controls (p value<0.001)
The mean serum sodium level in preeclamptics was 123.9±3.03 mmol/l and mean serum sodium levels in controls was 140.6±1.73 mmol/l. On applying significance test it was found that the difference in serum levels of sodium in both the groups was highly significant (p value < 0.001).The mean serum potassium levels in preeclamptics were 2.49±0.23 mmol/l and mean potassium levels in controls was 3.96±0.32 mmol/l. On applying significance test it was found that the difference in serum levels of potassium in both the groups was highly significant (p value < 0.001).
Conclusion: IMA generated by hypoxia/ischemia driven oxidative stress is raised in PE, hence it can be used as a biomarker in PE.
Serum sodium level was observed to be reduced in pre-eclamptics as compared to normotensive pregnant and non-pregnant women. The identification and counselling of preeclampsia relies fundamentally on the frequency of antenatal care and if their blood pressure was measured during the visit. Many women with pre-eclampsia, particularly, at the community level are missed due to the lack of antenatal care.
Key words: Pre-eclampsia, IMA, Electrolytes